Job Location: Nanjing， China Responsibilities: - The candidate will develop innovative therapeutic approaches for adoptive immunotherapy of tumors by implementing inventive strategies integrated in the CAR-T cell platforms. - Lead the design and execution of process development studies using QBD principles to develop a thorough understanding of operation performance parameters for T cell manufacturing process. - Lead from the lab to advance novel and differentiated cell therapy products toward clinical milestones， by working collaboratively with internal cross-functional teams and external partners. - Evaluate， develop， and implement functionally automatic and closed systems for T manufacturing process. - Oversee development activities for platform production processes and ensure processes are suitable for early-stage cGMP clinical development. - Perform in-vitro cellular assays involving flow cytometry， cytotoxicity， and functional characterization of genetically engineered primary T cells. - Support the technology transfer of the manufacturing process within Legend as assigned. - Accurately capture data in a timely manner， ensuring data integrity and protocol compliance. Qualifications: - PhD in Biological Sciences or related fields with 2 + years of experience working knowledge of T-cells or immunological cell therapies. - Strong scientific creativity and analytical thinking skills - More experience on T cells manufacturing include selection， activation， transduction， expansion， formulation and cryopreservation - Experience with automatic and closed systems or early technology evaluations for allogenic CAR-T cells processing are highly desirable. - Experience with cell-based functional assays using engineered and/or primary human cells are preferred. - Good working knowledge in cGMP manufacturing of biological process and ICH regulations. - Good coordination and communication skills are required. Highly organized and efficient， able to work independently. - Strong problem-solving skill is preferred. Ability to coordinate parallel tasks across multiple projects， demonstrating prioritization. - Comfortable operating in a fast-paced environment and able to multi-task and adjust workload based upon changing priorities